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Myriad Genetics Announces Patent Granted for SneakPeek® Snap Device

SALT LAKE CITY, March 20, 2024 (GLOBE NEWSWIRE) — Myriad Genetics, Inc., (NASDAQ: MYGN), a leader in genetic testing and precision medicine, today announced that the U.S. Patent and Trademark Office has granted a patent that covers the use of push-button blood collection devices for PCR-based fetal sex determination. Myriad Genetics Announces Patent Granted for SneakPeek® Snap Device

MediciNova Announces Two Abstracts regarding MN-001 (tipelukast) and MN-002 Accepted for Presentation at the 92nd EAS 2024 Congress, the Annual Meeting of the European Atherosclerosis Society

LA JOLLA, Calif., March 20, 2024 (GLOBE NEWSWIRE) — MediciNova, Inc., a biopharmaceutical company traded on the NASDAQ Global Market (NASDAQ:MNOV) and the Standard Market of the Tokyo Stock Exchange (Code Number: 4875), today announced that two abstracts entitled “STUDY PROTOCOL TO EVALUATE MN-001’S (TIPELUKAST) EFFICACY, SAFETY AND TOLERABILITY IN SUBJECTS WITH NON-ALCOHOLIC FATTY LIVER DISEASE (NAFLD), HYPERTRIGLYCERIDEMIA (HTG) AND TYPE-2 DIABETES MELLITUS (T2DM)” and “MN-002, THE METABOLITE OF MN-001(TIPELUKAST) PROMOTES MACROPHAGE CHOLESTEROL EFFLUX” have been accepted and selected for poster presentation at the 92nd European Atherosclerosis Society (EAS) 2024 Congress to be held May 26-29, 2024. MediciNova Announces Two Abstracts regarding MN-001 (tipelukast) and MN-002 Accepted for Presentation at the 92nd EAS 2024 Congress, the Annual Meeting of the European Atherosclerosis Society

Roche eröffnet Entwicklungszentrum für Gentherapie in Penzberg

In der neuen Hightech-Einrichtung treibt Roche künftig die Entwicklung von Genvektoren für neuartige Gentherapien voran. Zudem sollen diese hier im Industriemaßstab für klinische Studien hergestellt werden. Diese Genvektoren, oder auch „Genfähren“ genannt, eröffnen als Transportvehikel für DNA völlig neuartige Möglichkeiten, die Ursachen verschiedenster schwerer Erkrankungen auf DNA-Ebene zu behandeln und künftig sogar heilen zu können. Laut der American Society of Gene & Cell Therapy (ASGCT) wurden Ende 2023 weltweit mehr als 2.000 Gentherapien und genetisch modifizierte Zelltherapien erforscht. In der EU und somit in Deutschland sind aktuell 15 Gentherapien zugelassen (Quelle: Verband der forschenden Arzneimittelhersteller, VfA, Februar 2024).

Clinical proteomics: 100x more robust and 10x faster

A revolutionary approach simplifies and enhances the proteomic analysis of minimal cell quantities and liquid biopsies, setting a new standard in sensitivity, throughput, and robustness. By streamlining sample preparation for mass spectrometry, the Evotip workflow enables the seamless, cost-effective identification of proteins from biological matrices like blood plasma. This advancement paves the way for unprecedented insights into diseases at a molecular level, facilitating the discovery of precise biomarkers and therapeutic targets. Evotip based workflows not only accelerate scientific discovery but also makes state-of-the-art proteomics more accessible, promising significant strides in personalized medicine and beyond https://www.nature.com/articles/s41467-024-46777-9.epdf

NVIDIA Generative AI:  Drug Discovery and Design

NVIDIA BioNeMo, which is fueling the computer-aided drug discovery ecosystem, now features more than a dozen generative AI models and cloud services. In perhaps the healthcare industry’s most dramatic transformation since the advent of computing, digital biology and generative AI are helping to reinvent drug discovery, surgery, medical imaging and wearable devices. NVIDIA Generative AI Is Opening the Next Era of Drug Discovery and DesignNVIDIA BioNeMo, which is fueling the computer-aided drug discovery ecosystem, now features more than a dozen generative AI models and cloud services.January 8, 2024 by Kimberly Powell Share  In perhaps the healthcare industry’s most dramatic transformation since the advent of computing, digital biology and generative AI are helping to reinvent drug discovery, surgery, medical imaging and wearable devices. NVIDIA has been preparing for this moment for over a decade, building deep domain expertise, creating the NVIDIA… 

Ransomware-Angriff eines Anbieters legt Patientendaten in einem Krankenhaus in Tennessee offen

Die Informationen von Regional One Health mit Sitz in Memphis, Tennessee, in den Bereichen Geburtshilfe und Gynäkologie könnten durch einen Ransomware-Angriff auf den Technologieanbieter KMJ Health Solutions kompromittiert worden sein. Am 18. Januar teilte KMJ dem University of Tennessee Health Science Center, das Bewohner von Regional One versorgt, mit, dass sein Hosting-Anbieter Liquid Web Anzeichen […] Ransomware-Angriff eines Anbieters legt Patientendaten in einem Krankenhaus in Tennessee offen

CRISPR-based diagnostics detecting oral pathogens

The study, by Batbileg Bor of the ADA Forsyth Institute, Cambridge, MA, USA, tailored the novel CRISPR-Cas-based diagnostic platform Specific High-Sensitivity Enzymatic Reporter Unlocking (SHERLOCK) for the species-specific detection of oral bacterial pathogens and human papillomavirus (HPV) nucleic acids. The investigators developed a computational pipeline capable of generating guide-RNAs and species-specific gene primers suitable for SHERLOCK. These constructs were synthesized by cell-free biosynthesis systems, and their specificity and sensitivity were experimentally validated by fluorescence readings of reporter RNAs. The study achieved the detection of oral bacteria within the single-molecule range that remained specific in the presence of off-target DNA found within saliva. Furthermore, the assay was refined for detecting common oral pathogens (e.g., P. gingivalis, F. nucleatum) directly from unprocessed saliva samples. The results of the detection, when tested on 30 patient saliva samples, fully aligned with those of other… 

Early leukemia diagnostics breakthrough

A research team from the Institute of Physical Chemistry of the Polish Academy of Sciences have demonstrated a unique configuration of a system based on optical tweezers – which enables long-distance manipulation of various particles and cells in lab-on-the-chip devices – to enable fast and effective diagnosis and treatment of many serious diseases. The volume of the information microfluidics can unlock, combined with its speed, accuracy and specificity can become the difference between life and death in diagnosing deadly diseases such as cancer. This possibility of early-stage diagnosis of blood cancer – better known as leukemia – was the motivation of the Polish team in building an innovative microfluidics-based diagnostic device. https://pubs.rsc.org/en/content/articlelanding/2024/lc/d3lc00733b

Klimawandel befeuert Ausbreitung von Infektionskrankheiten

Ein jetzt in JAMA veröffentlichter Artikel schlägt Alarm hinsichtlich der Entstehung und Ausbreitung schädlicher Krankheitserreger. Die Autoren fordern die medizinische Gemeinschaft außerdem auf, ihre Aus- und Weiterbildung zu aktualisieren und Maßnahmen zur Bekämpfung der globalen Erwärmung zu ergreifen. Infektionskrankheiten können durch Viren, Bakterien, Pilze oder Parasiten verursacht werden. Viele dieser Krankheiten werden von Tier zu Mensch oder von Mensch zu Mensch übertragen. Eine Art von Infektionskrankheiten sind durch Vektoren übertragene Krankheiten . Sie werden durch Krankheitserreger verursacht, die von Vektoren wie Mücken, Flöhen und Zecken übertragen werden. Einige durch Vektoren verursachte Krankheiten sind Denguefieber , Malaria und Zika . Die Studie wies auch auf das Auftreten neuer Pilzinfektionen wie Candida auris (C. auris) und Veränderungen im Standort einiger Pilzpathogene hin . Beispielsweise war die Pilzinfektion Coccidioides (auch als Valley-Fieber bekannt ) in heißen, trockenen Gebieten in Kalifornien und Arizona endemisch.…