Lab-grown human tissue successfully repairs damaged intestines in rodent model. Achievement led by experts at Cincinnati Children’s moves years-long research effort closer to first-in-human clinical trial. Potential benefits include new therapies for ulcerative colitis, Crohn’s disease, and more.
In a study published online Sept. 12, 2024, in Cell Stem Cell, a team of experts at Cincinnati Children’s reports the details of a milestone achievement in the emerging field of organoid medicine.
„Our cellular product was much more than a surface patch over intestinal damage. We could see that the cells we introduced induced repairs across all the important layers of the intestine, including the musculature of the mesenchyme and the internal protective surface layer, or epithelium.“ Poling says. „We confirmed the formation of a variety of cell types and all of them were human, including new blood vessel incorporation. The repaired regions showed appropriate barrier function, too. We could see cells responding to chemicals in the ways that they should respond.“
