On the occasion of World AIDS Day on 1 December 2024, the International Antiviral (formerly AIDS) Society-USA (IAS-USA) has published new international guidelines for the treatment and prevention of HIV. The updated recommendations were developed by a panel of volunteer medical experts, including DZIF scientist Prof Clara Lehmann of the University Hospital Cologne. They are based on significant advances in antiretroviral therapies and new prevention strategies such as pre-exposure prophylaxis. The 2024 guidelines highlight the significant progress made in the fight against HIV while recognising that there is still much to be done to ensure equitable access to life-saving interventions.
An international panel of leading experts in HIV research and clinical care identified and reviewed the latest evidence from peer-reviewed literature and conference presentations published between June 2022 and October 2024, as well as data provided by antiretroviral manufacturers. Expert consensus based on the comprehensive review resulted in updated guidelines for the treatment and prevention of HIV infection, associated sexually transmitted infections and the development of cardiovascular disease in people living with HIV. Below is an overview of the recommendations for HIV treatment, prevention and care.
Tailored antiretroviral therapy
The panel recommends that antiretroviral therapy should be tailored to the individual’s needs, especially for those who cannot tolerate certain HIV drugs. Long-acting injectable therapies are highlighted as a valuable option to help patients adhere to their treatment plans.
HIV prevention strategies
For people at increased risk of HIV exposure, the guidelines emphasise the use of pre-exposure prophylaxis, available as daily oral medication or long-acting injectable options. In addition, doxycycline is recognised as an effective post-exposure prophylaxis to prevent sexually transmitted infections.
Comprehensive care for people living with HIV
The panel stresses the importance of a holistic approach to HIV care. This includes prevention of cardiovascular disease, management of substance use disorders and monitoring of weight changes that may occur during antiretroviral therapy.
The International Antiviral (formerly AIDS) Society-USA (IAS-USA) is dedicated to advancing global health by promoting evidence-based approaches to the prevention and management of HIV and related diseases. For more information, visit https://www.iasusa.org.
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